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Call for Contributions: New Book on Intrathecal Drug Delivery in the NEUROMETHODS Series by Springer Nature

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I am pleased to announce that I am editing a new volume titled "Intrathecal Drug Delivery", which will be published as part of the...

Targeting soluble Abeta oligomers in the CSF via intrathecal pseudodelivery

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Hypothetical changes in Aβ oligomers during disease progression are transferred to the model of AD biomarker changes, according to Jack et a...

Toward a new nosology of neurodegenerative diseases. Implementing a tridimensional diagnostic annotation system

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New “omic” technologies are revealing shared and distinct biological pathways within and across neurodegenerative diseases (NDDs), allowing ...

Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

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Intrathecal pseudodelivery is a specialized drug delivery method where the therapeutic agent is introduced into a reservoir connected to th...

A variant in GRN of Spanish origin presenting with heterogeneous phenotypes

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A. Marked depletion of motor neurons from the anterior horn of the spinal cord (H&E). B. Motor neuron filiform cytoplasmic inclusion is ...

New, Fully Implantable Device for Selective Clearance of CSF-Target Molecules: Proof of Concept in a Murine Model of Alzheimer’s Disease

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We have previously proposed a radical change in the current strategy to clear pathogenic proteins from the central nervous system (CNS) base...

Intermediate and Expanded HTT Alleles and the Risk for α-Synucleinopathies

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Background Previous studies suggest a link between CAG repeat number in the HTT gene and non-Huntington neurodegenerative diseases. Objecti...

The “Cerebrospinal Fluid Sink Therapeutic Strategy” in Alzheimer’s Disease—From Theory to Design of Applied Systems

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Alzheimer’s disease (AD) is a global health problem, with incidence and prevalence considered to increase during the next decades. However, ...

Smoking is associated with age at disease onset in Parkinson's disease

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Background Previous studies linked disease-progression variables such as age at onset or survival to both genetic, and non-genetic factors i...

Cancer in Parkinson Disease: an approximation to the main risk factors

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Background: Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies...

Impact of Depression and Anxiety on Dimensions of Health-Related Quality of Life in Subjects with Parkinson’s Disease Enrolled in an Association of Patients

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Parkinson’s disease (PD) is a complex disorder characterized by a wide spectrum of symptoms. Depression and anxiety are common manifestation...

A series of cases with Huntington-like phenotype and intermediate repeats in HTT

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Here we describe the larger series of clinical cases (n = 14) with HD-like phenotype and IAs published to date.  MRI and FDG-PET neuroimagin...

Patients with Parkinson’s Disease Show Alteration in their Visuospatial Abilities and in their Egocentric and Allocentric Spatial Orientation Measured by Card Placing Tests

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Background: Visuospatial skills are impaired in Parkinson's disease (PD). Other related skills exist, such as spatial orientation have b...

Genetic variation in APOE, GRN and TP53 are phenotype modifiers in frontotemporal dementia

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Frontotemporal dementia (FTD) is a clinical, genetic and pathological heterogeneous group of neurodegenerative diseases. In this study, we i...

A role for ATXN1, ATXN2 and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease

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We analyzed the frequency of intermediate alleles (IAs) in the ATXN1, ATXN2 and HTT genes in several neurodegenerative diseases. The study...

The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population‐Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight

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Background The Iberian Peninsula stands out as having variable levels of population admixture and isolation, making Spain an interesting se...

Albumin Exchange in Alzheimer's Disease: Might CSF Be an Alternative Route to Plasma?

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Amyloid β (Aβ) in brain parenchyma is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). Aβ is transport...

Prevalence of Depression and Anxiety in Parkinson Disease and Impact on Quality of Life: A Community-Based Study in Spain

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Background: Identifying neuropsychiatric disorders is essential for prompt treatment to reduce morbidity. Among these disorders, anxiety an...